Total synthesis and related studies of large, strained, and bioactive natural products
نویسنده
چکیده
Our chemical syntheses and related scientific investigations of natural products with complex architectures and powerful biological activities are described, focusing on the very large 3 nm-long polycyclic ethers called the ciguatoxins, highly strained and labile chromoprotein antitumor antibiotics featuring nine-membered enediyne cores, and extremely potent anthelmintic macrolides called the avermectins.
منابع مشابه
Synthesis and Purification of 7-Prenyloxycoumarins and Herniarin as Bioactive Natural Coumarins
Objective(s) 7-prenyloxycoumarins including 7-isopentenyloxycoumarin, auraptene and umbelliprenin, and herniarin have been widely recognized as bioactive coumarins. This paper presents the ways to synthesis these compounds. Materials and Methods 7-prenyloxycoumarins were synthesized by reaction between 7-hydroxycoumarin (' M) and relevant prenyl bromides (1.5 M) in acetone at room temperatur...
متن کاملChemical composition and antioxidant properties of some species of Lamiaceae family from Iran
Spearmint (Mentha spicata L.), oregano (Origanum vulgare L.) and thyme (Thymus vulgaris L.) are used as traditional medicines, culinary herbs and food flavorings. All samples collected from Khuzestan province, Iran and plant extracts prepared using Clevenger apparatus. Antioxidant capacity and major parameters affecting antioxidant properties including total phenolics, flavonoids and vitamin C ...
متن کاملMarine cytotoxic macrolides haterumalides and biselides, and related natural products.
Marine animals and plants are rich sources of bioactive natural products. Haterumalides and biselides, isolated from Okinawan marine animals, are 14-membered macrolides with strong cytotoxicity against human cancer cell lines. This review highlights the isolation, structures, bioactivities, and total synthesis of haterumalides, biselides, and related natural products.
متن کاملTotal synthesis and development of bioactive natural products
The first total synthesis and development of a variety of bioactive natural products have been accomplished by using carbohydrates as a chiral source. In addition, practically useful intermediates have been created, analogs of natural products have been prepared, their structure-activity relationships studied, and the large-scale preparations of medicinally useful compounds established. The key...
متن کاملCase studies of the synthesis of bioactive cyclodepsipeptide natural products.
Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis. Although cyclodepsipeptides feature highly diverse chemical structures, their synthesis is often associated with similar synthetic challenges such as the establishment of a suitable macrocyclization methodolog...
متن کامل